Alan Daugherty Selected Research

Abdominal Aortic Aneurysm

1/2022	Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease.
1/2021	No Effect of Hypercholesterolemia on Elastase-Induced Experimental Abdominal Aortic Aneurysm Progression.
1/2021	Vasohibin-2 Aggravates Development of Ascending Aortic Aneurysms but not Abdominal Aortic Aneurysms nor Atherosclerosis in ApoE-Deficient Mice.
1/2021	Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.
1/2021	Effects of Endogenous Angiotensin II on Abdominal Aortic Aneurysms and Atherosclerosis in Angiotensin II-Infused Mice.
1/2020	Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation.
1/2020	Hypercholesterolemia Accelerates Both the Initiation and Progression of Angiotensin II-induced Abdominal Aortic Aneurysms.
11/2019	Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
2/2019	Ginkgo biloba extracts prevent aortic rupture in angiotensin II-infused hypercholesterolemic mice.
1/2019	One amino acid change of Angiotensin II diminishes its effects on abdominal aortic aneurysm.

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Alan Daugherty Research Topics

Disease

85	Atherosclerosis 01/2021 - 01/2002
62	Abdominal Aortic Aneurysm 01/2022 - 03/2003
21	Inflammation (Inflammations) 11/2021 - 02/2002
18	Rupture 10/2020 - 08/2006
17	Hypercholesterolemia 01/2022 - 12/2004
17	Aortic Aneurysm (Aneurysm, Aortic) 01/2022 - 05/2010
16	Aneurysm (Aneurysms) 01/2020 - 03/2003
12	Aortic Rupture 01/2022 - 08/2005
11	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 06/2002
10	Thoracic Aortic Aneurysm 10/2021 - 01/2010
9	Ascending Aorta Aneurysm 12/2021 - 04/2008
9	Body Weight (Weight, Body) 10/2020 - 01/2003
8	Obesity 01/2018 - 10/2009
6	Sepsis (Septicemia) 01/2021 - 07/2009
6	Vascular Diseases (Vascular Disease) 02/2019 - 04/2004
5	Hypertension (High Blood Pressure) 01/2022 - 02/2008
5	Aortic Dissection 01/2022 - 09/2003
5	Atherosclerotic Plaque (Atheroma) 01/2021 - 02/2008
5	Thrombosis (Thrombus) 01/2019 - 02/2002
3	Hyperlipidemias (Hyperlipidemia) 01/2021 - 02/2002
2	Hemorrhage 01/2022 - 06/2006
2	COVID-19 10/2020 - 06/2020
2	Dyslipidemias (Dyslipidemia) 01/2020 - 08/2015
2	Fatty Liver 12/2019 - 02/2016
2	Hyperplasia 09/2015 - 02/2010
2	Hypertrophy 10/2012 - 02/2010
2	Coronary Artery Disease (Coronary Atherosclerosis) 02/2012 - 06/2003

Drug/Important Bio-Agent (IBA)

72	Angiotensin IIIBA 01/2022 - 03/2003
31	Apolipoproteins E (ApoE)IBA 01/2021 - 06/2002
28	LDL Receptors (LDL Receptor)IBA 01/2022 - 03/2002
23	Lipoproteins (Lipoprotein)IBA 10/2019 - 01/2002
17	ApolipoproteinsIBA 01/2021 - 02/2002
16	CholesterolIBA 01/2021 - 05/2002
11	CytokinesIBA 01/2021 - 09/2005
10	LipidsIBA 01/2021 - 06/2003
8	AngiotensinsIBA 10/2020 - 12/2004
7	AngiotensinogenIBA 01/2021 - 12/2004
6	LigandsIBA 10/2021 - 10/2004
6	Phenobarbital (Luminal)FDA Link 02/2019 - 02/2002
5	Angiotensin-Converting Enzyme 2IBA 10/2020 - 04/2011
5	ReninIBA 10/2020 - 03/2008
5	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020 - 03/2002
5	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2012
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 02/2012 - 09/2005
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 12/2006
4	oxidized low density lipoproteinIBA 01/2018 - 06/2004
4	Matrix Metalloproteinases (MMPs)IBA 05/2017 - 03/2003
4	Messenger RNA (mRNA)IBA 01/2012 - 01/2005
4	Peptides (Polypeptides)IBA 08/2011 - 12/2004
3	Transcription Factors (Transcription Factor)IBA 11/2021 - 09/2014
3	Triglycerides (Triacylglycerol)IBA 01/2021 - 03/2009
3	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2020 - 09/2013
3	Angiotensin IIBA 01/2020 - 09/2013
3	SaltsIBA 01/2020 - 07/2013
3	Losartan (Cozaar)FDA LinkGeneric 12/2019 - 07/2013
3	AldosteroneIBA 01/2018 - 02/2005
3	Glucose (Dextrose)FDA LinkGeneric 05/2015 - 01/2011
3	HDL LipoproteinsIBA 05/2014 - 07/2009
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 09/2013 - 09/2007
3	Interferon-gamma (Interferon, gamma)IBA 01/2009 - 02/2002
3	Interleukin-4 (Interleukin 4)IBA 12/2007 - 03/2002
2	Fibrillin-1IBA 10/2021 - 05/2019
2	Prorenin ReceptorIBA 01/2021 - 01/2018
2	Pancreatic Elastase (Elastase)IBA 01/2021 - 01/2021
2	Proprotein Convertase 9IBA 01/2021 - 01/2016
2	Low Density Lipoprotein Receptor-Related Protein-2IBA 01/2020 - 01/2019
2	Amino Acids FDA Link 01/2020 - 01/2019
2	ElastinIBA 05/2019 - 07/2013
2	LipopolysaccharidesIBA 01/2019 - 01/2013
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2018 - 05/2017
2	Acetates (Acetic Acid Esters)FDA Link 01/2018 - 07/2013
2	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2018 - 07/2013
2	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2018 - 07/2013
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2017 - 08/2010
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017 - 01/2016
2	Testosterone (Sustanon)FDA Link 01/2017 - 05/2012
2	Renin InhibitorsIBA 02/2016 - 03/2008
2	Antisense OligonucleotidesIBA 02/2016 - 01/2016
2	aliskiren FDA Link 02/2016 - 03/2008
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 05/2015 - 02/2014
2	salicylhydroxamic acid (SHAM)IBA 03/2015 - 08/2004
2	Pharmaceutical PreparationsIBA 10/2014 - 12/2006
2	Orphan Nuclear ReceptorsIBA 09/2014 - 08/2010
2	Scavenger Receptors (Scavenger Receptor)IBA 05/2014 - 07/2009
2	Enalapril FDA LinkGeneric 09/2013 - 07/2013
2	Type 1 Angiotensin ReceptorIBA 07/2013 - 10/2012
2	Spironolactone (Aldactone)FDA LinkGeneric 07/2013 - 02/2005
2	Interleukin-6 (Interleukin 6)IBA 03/2013 - 01/2013
2	SmokeIBA 09/2012 - 06/2010
2	Doxycycline (Periostat)FDA LinkGeneric 01/2012 - 03/2003
2	AcidsIBA 03/2009 - 06/2003
2	ZincIBA 11/2007 - 09/2005

Therapy/Procedure

10	Therapeutics 01/2021 - 02/2008
5	Ligation 01/2021 - 07/2009
4	Punctures 01/2021 - 07/2009
4	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/2014 - 02/2007
3	Subcutaneous Infusions 09/2015 - 04/2008
2	Intraperitoneal Injections 01/2021 - 01/2013
2	Castration 03/2015 - 07/2008
2	Operative Surgical Procedures 01/2015 - 10/2012